Aug 07 2024
Sewwandi S Rathnayake, Satchal K Erramilli, Anthony A Kossiakoff, Alex J Vecchio
Science Direct Structure 8 October 2024
PMID: 39383874 DOI:10.1016/j.str.2024.09.015
Pathogenic strains of Clostridium perfringens secrete an enterotoxin (CpE) that causes prevalent, severe, and sometimes deadly gastrointestinal disorders in humans and domesticated animals. CpE binds selectively to membrane protein receptors called claudins on …
Aug 07 2024
Satchal K Erramilli, Pawel K Dominik, Chinemerem P Ogbu, Anthony A Kossiakoff, Alex J Vecchio
Commun Biol. 2024 Jun 17;7(1):733. doi: 10.1038/s42003-024-06437-6.
PMID: 38886509 PMCID: PMC11183071 DOI: 10.1038/s42003-024-06437-6
Claudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial …
Jun 20 2024
Tong Lan, Tomasz Slezak, Jinyue Pu, Julia Zinkus-Boltz, Sarbani Adhikari, Joel R. Pekow, Vibha Taneja, Joaquin Zuniga, Itzel A. Gómez-García, Nora Regino-Zamarripa, Mushtaq Ahmed, Shabaana A. Khader, David T. Rubin, Anthony A. Kossiakoff, and Bryan C. Dickinson
ACS Chem. Biol. June 6, 2024 © 2024 American Chemical Society
PMID: 38843544 DOI: 10.1021/acschembio.4c00265
Calprotectin, a metal …
Jun 20 2024
Lin Zhang, Hong-Chao Duan, Marcin Paduch, Jingyan Hu, Chi Zhang, Yajuan Mu, Houwen Lin, Chuan He, Anthony A. Kossiakoff, Guifang Jia, Liang Zhang
Zitierweise: Angew. Chem. Int. Ed. 2024, 63, e202313900
PMID: 38158383 DOI: 10.1002/ange.202313900
N1-methyladenosine (m1A) is a prevalent post-transcriptional RNA modification, and the distribution and dynamics of the modification play key epitranscriptomic roles …
Apr 03 2024
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P Locher
Nature Communications volume 15, Article number: 2476 (2024)
PMID: 38509088 PMCID: PMC10954734 DOI: 10.1038/s41467-024-46706-w
Cellular entry of the hepatitis B and D viruses (HBV/HDV) …
Apr 03 2024
Szymon P. Kordon, Kristina Cechova, Sumit J. Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A. Kossiakoff, Reza Vafabakhsh, and Demet Araç
bioRxiv 2024 Feb 26
PMID: 38464178 DOI: 10.1101/2024.02.25.581807
Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECR) containing a conserved GAIN …
Nov 21 2023
Heather A Bruce, Alexander U Singer, Ekaterina V Filippova, Levi L Blazer, Jarrett J Adams, Leonie Enderle, Moshe Ben-David, Elizabeth H Radley, Daniel Y L Mao, Victor Pau, Stephen Orlicky, Frank Sicheri, Igor Kourinov, Shane Atwell, Anthony A Kossiakoff, Sachdev S Sidhu
Protein Sci. 2023 Nov 9:e4824.
PMID: 37945533 DOI: 10.1002/pro.4824
The atomic-resolution structural information …
Nov 06 2023
Rosemary J. Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K. Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C. Choy, Zhening Zheng, Oliver B. Clarke, Sook Wah Yee, Anthony A. Kossiakoff, Matthias Quick, Thomas Arnold, Filippo Mancia
bioRxiv. 2023 Oct 5:2023.10.05.561059.
PMID: 37873173 PMCID: PMC10592973 DOI: 10.1101/2023.10.05.561059
Choline is an essential …
Oct 17 2023
Anca-Denise Ciută, Kamil Nosol, Julia Kowal, Somnath Mukherjee, Ana S. Ramírez, Bruno Stieger, Anthony A. Kossiakoff & Kaspar P. Locher
Nature Communications volume 14, Article number: 5774 (2023)
PMID: 37723174 PMCID: PMC10507018 DOI: 10.1038/s41467-023-41552-8
The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane proteins that mediate uptake of drugs into the liver for subsequent conjugation and biliary …
Oct 17 2023
Paweł P Knejski, Satchal K Erramilli, Anthony A Kossiakoff
bioRxiv. 2023 Aug 1:2023.08.01.551527.
PMID: 37577460 PMCID: PMC10418163 DOI: 10.1101/2023.08.01.551527
Pathogenic bacteria, such as Pseudomonas aeruginosa , depend on scavenging heme for the acquisition of iron, an essential nutrient. The TonB-dependent transporter (TBDT) PhuR is the major heme uptake protein in P. aeruginosa clinical isolates. However, a comprehensive understanding …