Apr 03 2024
Nature Communications volume 15, Article number: 2476 (2024)
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P Locher
PMID: 38509088 PMCID: PMC10954734 DOI: 10.1038/s41467-024-46706-w
Cellular entry of the hepatitis B and D viruses (HBV/HDV) …
Apr 03 2024
Szymon P. Kordon, Kristina Cechova, Sumit J. Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A. Kossiakoff, Reza Vafabakhsh, and Demet Araç
bioRxiv Preprint. 2024 Feb 26
PMID: 38464178 DOI: 10.1101/2024.02.25.581807
Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECR) containing a conserved …
Nov 06 2023
Rosemary J. Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K. Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C. Choy, Zhening Zheng, Oliver B. Clarke, Sook Wah Yee, Anthony A. Kossiakoff, Matthias Quick, Thomas Arnold, Filippo Mancia
bioRxiv. 2023 Oct 5:2023.10.05.561059.
PMID: 37873173 PMCID: PMC10592973 DOI: 10.1101/2023.10.05.561059
Choline is an essential …
Oct 17 2023
Paweł P Knejski, Satchal K Erramilli, Anthony A Kossiakoff
bioRxiv. 2023 Aug 1:2023.08.01.551527.
PMID: 37577460 PMCID: PMC10418163 DOI: 10.1101/2023.08.01.551527
Pathogenic bacteria, such as Pseudomonas aeruginosa , depend on scavenging heme for the acquisition of iron, an essential nutrient. The TonB-dependent transporter (TBDT) PhuR is the major heme uptake protein in P. aeruginosa clinical isolates. However, a comprehensive understanding …
Aug 08 2023
Susan A Leonhardt, Michael D Purdy, Jonathan R Grover, Ziwei Yang, Sandra Poulos, William E McIntire, Elizabeth A Tatham, Satchal K Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D Uchil, Andrés Finzi, Alan Rein, Anthony A Kossiakoff, Walther Mothes, Mark Yeager
Nature Communications volume 14, Article number: 4368 (2023)
PMID: 37474505 …
Aug 08 2023
Qiuyan Chen, Christopher T Schafer, Somnath Mukherjee, Martin Gustavsson, Parth Agrawal, Xin-Qiu Yao, Anthony A Kossiakoff, Tracy M Handel, John J G Tesmer
bioRxiv 2023 Jul 19, 2023
PMID: 37502840 PMCID: PMC10370059 DOI: 10.1101/2023.07.18.549504
Atypical chemokine receptor 3 (ACKR3, also known as CXCR7) is a scavenger receptor that regulates extracellular levels of the chemokine CXCL12 …
Aug 03 2023
Satchal K Erramilli, Pawel K Dominik, Chinemerem P Ogbu, Anthony A Kossiakoff, Alex J Vecchio
bioRxiv 2023 Jun 12, 2023
PMID: 37398044 PMCID: PMC10312657 DOI: 10.1101/2023.06.12.544689
Claudins are a family of ∼25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells. Humans have 27 subtypes, which homo- and hetero-oligomerize to …
Apr 03 2023
Karthik Srinivasan, Satchal K. Erramilli, Srinivas Chakravarthy, Adrian Gonzalez, Anthony Kossiakoff, Nicholas Noinaj
Structure. 2023 Mar 17; S0969-2126(23)00078-3.
PMID: 36977410 DOI: 10.1016/j.str.2023.03.002
Roughly 95% of the proteins that make up the chloroplast must be imported from the cytoplasm. The machinery responsible for the translocation of these cargo proteins is called the translocon at the outer …
Mar 23 2023
David M Kern, Julia Bleier, Somnath Mukherjee, Jennifer M Hill, Anthony A Kossiakoff, Ehud Y Isacoff, Stephen G Brohawn
Nat Struct Mol Biol 2023 Mar 16
PMID: 36928458 DOI: 10.1038/s41594-023-00944-6
Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously expressed in vertebrate cells as …
Aug 08 2022
Yu-Chen Yen, Christopher T Schafer, Martin Gustavsson, Stefanie A Eberle, Pawel K Dominik, Dawid Deneka, Penglie Zhang, Thomas J Schall, Anthony A Kossiakoff, John J G Tesmer, Tracy M Handel
Sci Adv. 2022 Jul 15;8(28):eabn8063.
PMID: 35857509 PMCID: PMC9278869 DOI: 10.1126/sciadv.abn8063
Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are activated by …