Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2

Philipp Ross, Hugo G. Hilton, Jane Lodwick, Tomasz Slezak, Lisbeth A. Guethlein, Curtis P. McMurtrey, Alex S. Han, Morten Nielsen, Daniel Yong, Charles L. Dulberger, Kristof T. Nolan, Sobhan Roy, Caitlin D. Castro, William H. Hildebrand, Minglei Zhao, Anthony Kossiakoff, Peter Parham, Erin J. Adams

bioRxiv 2024 Nov 28:2024.11.25.625330.

PMID: 39651149 PMCID: PMC11623575 DOI: 10.1101/2024.11.25.625330

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Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Szymon P Kordon, Kristina Cechova, Sumit J Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A Kossiakoff, Reza Vafabakhsh, Demet Araç

Nature Communications 2024 Dec 4;15:10545.

PMID: 39627215 PMCID: PMC11615224 DOI: 10.1038/s41467-024-54836-4

Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECRs) containing a …

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Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule

Chinemerem P Ogbu, Alexandria M Mandriota, Xiangdong Liu, Mason de las Alas, Srajan Kapoor, Jagrity Choudhury, Anthony A Kossiakoff, Michael E Duffey, Alex J Vecchio

bioRxiv 2024 Nov 11:2024.11.10

PMID: 39605593 PMCID: PMC11601404 DOI: 10.1101/2024.11.10.622873

Claudins are a 27-member protein family that form and fortify specialized cell contacts in endothelium and epithelium called tight junctions. …

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