Tag: synthetic antibody fragments

Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes

Benjamin J. Orlando, Pawel K. Dominik, Sourav Roy, Chinemerem P. Ogbu, Satchal K. Erramilli, AnthonyA. Kossiakoff, Alex J. Vecchio

JBC Journal of Biological Chemistry 9 August 2022, 102357

DOI: jbc.2022.102357

Strains of Clostridium perfringens produce a two-domain enterotoxin (CpE) that afflicts humans and domesticated animals, causing prevalent gastrointestinal illnesses. CpE’s C-terminal domain (cCpE) binds cell …

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