Judy Luke
Author's posts
May 03 2023
2023 NAS Election
News from the National Academy of Sciences
Newly elected member Anthony A. Kossiakoff; Professor, Department of Biochemistry and Molecular Biology, The University of Chicago
Three University of Chicago faculty members elected to the National Academy of Sciences in 2023
Apr 03 2023
Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum
Karthik Srinivasan, Satchal K. Erramilli, Srinivas Chakravarthy, Adrian Gonzalez, Anthony Kossiakoff, Nicholas Noinaj
Structure. 2023 Mar 17; S0969-2126(23)00078-3.
PMID: 36977410 DOI: 10.1016/j.str.2023.03.002
Roughly 95% of the proteins that make up the chloroplast must be imported from the cytoplasm. The machinery responsible for the translocation of these cargo proteins is called the translocon at the outer …
Mar 23 2023
Structural basis for assembly and lipid-mediated gating of LRRC8A: C volume-regulated anion channels
David M Kern, Julia Bleier, Somnath Mukherjee, Jennifer M Hill, Anthony A Kossiakoff, Ehud Y Isacoff, Stephen G Brohawn
Nat Struct Mol Biol 2023 Mar 16
PMID: 36928458 DOI: 10.1038/s41594-023-00944-6
Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously expressed in vertebrate cells as …
Feb 13 2023
Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
Szymon P Kordon, Przemysław Dutka, Justyna M Adamska, Sumit J Bandekar, Katherine Leon, Satchal K Erramilli, Brock Adams, Jingxian Li, Anthony A Kossiakoff, Demet Araç
Nat Commun. 2023 Feb 6
PMID: 36746957 PMCID: PMC9902482 DOI: 10.1038/s41467-023-36312-7
Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular regions that bind to multiple ligands to regulate …
Feb 13 2023
Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase
Joël S Bloch, Alan John, Runyu Mao, Somnath Mukherjee, Jérémy Boilevin, Rossitza N Irobalieva, Tamis Darbre, Nichollas E Scott, Jean-Louis Reymond, Anthony A Kossiakoff, Ethan D Goddard-Borger, Kaspar P Locher
Nat Chem Biol. 2023 Jan 5
PMID: 36604564 DOI: 10.1038/s41589-022-01219-9
C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins …
Aug 15 2022
Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes
Benjamin J. Orlando, Pawel K. Dominik, Sourav Roy, Chinemerem P. Ogbu, Satchal K. Erramilli, AnthonyA. Kossiakoff, Alex J. Vecchio
JBC Journal of Biological Chemistry 9 August 2022, 102357
PMID: 35952760 PMCID: PMC9463536 DOI: jbc.2022.102357
Strains of Clostridium perfringens produce a two-domain enterotoxin (CpE) that afflicts humans and domesticated animals, causing prevalent gastrointestinal illnesses. CpE’s C-terminal domain …
Aug 08 2022
Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias
Yu-Chen Yen, Christopher T Schafer, Martin Gustavsson, Stefanie A Eberle, Pawel K Dominik, Dawid Deneka, Penglie Zhang, Thomas J Schall, Anthony A Kossiakoff, John J G Tesmer, Tracy M Handel
Sci Adv. 2022 Jul 15;8(28):eabn8063.
PMID: 35857509 PMCID: PMC9278869 DOI: 10.1126/sciadv.abn8063
Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are activated by …
Jul 05 2022
A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel
Peiqiang Feng, Xudong Wu, Satchal K Erramilli, Joao A Paulo, Pawel Knejski, Steven P Gygi, Anthony A Kossiakoff, Tom A Rapoport
Nature. 2022 Jun 29
PMID: 35768507 DOI: 10.1038/s41586-022-04903-x
Peroxisomes are ubiquitous organelles that house various metabolic reactions and are essential for human health1-4. Luminal peroxisomal proteins are imported from the cytosol by mobile receptors, which then …
Jul 05 2022
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver
Hongtao Liu, Rossitza N. Irobalieva, Rose Bang-Sørensen, Kamil Nosol, Somnath Mukherjee, Parth Agrawal, Bruno Stieger, Anthony A. Kossiakoff & Kaspar P. Locher
Cell Research (2022) 0:1–4
PMID: 35726088 DOI: 10.1038/s41422-022-00680-4
The sodium taurocholate (TC) co-transporting polypeptide NTCP (SLC10A1) is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood plasma …
Jul 05 2022
Architecture of the cytoplasmic face of the nuclear pore
Christopher J Bley, Si Nie, George W Mobbs, Stefan Petrovic, Anna T Gres, Xiaoyu Liu, Somnath Mukherjee, Sho Harvey, Ferdinand M Huber, Daniel H Lin, Bonnie Brown, Aaron W Tang, Emily J Rundlet, Ana R Correia, Shane Chen, Saroj G Regmi, Taylor A Stevens, Claudia A Jette, Mary Dasso, Alina Patke, Alexander F Palazzo, Anthony …