Judy Luke
Author's posts
Jul 23 2021
Structure of an AMPK complex in an inactive, ATP-bound state
Yan Yan, Somnath Mukherjee, Kaleeckal G. Harikumar, Timothy S. Strutzenberg, Edward Zhou, Kelly Suino-Powell, Ting-Hai Xu, Ryan D. Sheldon, Jared Lamp, Joseph S. Brunzelle, Katarzyna Radziwon, Abigail Ellis, Scott J. Novick, Irving E. Vega, Russell G. Jones, Laurence J. Miller, H. Eric Xu, Patrick R. Griffin, Anthony A. Kossiakoff, Karsten Melcher
Science 23 Jul 2021: …
Jul 20 2021
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1
Qiuyan Chen, Manolo Plasencia, Zhuang Li, Somnath Mukherjee, Dhabaleswar Patra, Chun-Liang Chen, Thomas Klose, Xin-Qiu Yao, Anthony A Kossiakoff, Leifu Chang, Philip C Andrews, John J G Tesmer
Nature. 2021 Jul 14. doi: 10.1038/s41586-021-03721-x
PMID: 34262173
G-protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate activated GPCRs, thereby priming them for desensitization1. Although it is unclear how …
Jul 13 2021
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle
Yuanyuan Yu, Qingyun Zheng, Satchal K. Erramilli, Man Pan, Seongjin Park, Yuan Xie, Jingxian Li, Jingyi Fei, Anthony A. Kossiakoff, Lei Liu & Minglei Zhao
Nat Chem Biol. 2021 Jul 8. doi: 10.1038/s41589-021-00823-5
PMID: 34239127
Protein ubiquitination shows remarkable topological and functional diversity through the polymerization of ubiquitin via different linkages. Deciphering the cellular ubiquitin …
Jul 06 2021
A T cell redirection platform for co-targeting dual antigens on solid tumors
Leonie Enderle, Karim H Shalaby, Maryna Gorelik, Alexander Weiss, Levi L Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J Adams, Sachdev S Sidhu
MAbs. Jan-Dec 2021;13(1):1933690. doi: 10.1080/19420862.2021.1933690
PMID: 34190031
In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell …
Jun 16 2021
Structural basis of omega-3 fatty acid transport across the blood-brain barrier
Rosemary J Cater, Geok Lin Chua, Satchal K Erramilli, James E Keener, Brendon C Choy, Piotr Tokarz, Cheen Fei Chin, Debra Q Y Quek, Brian Kloss, Joseph G Pepe, Giacomo Parisi, Bernice H Wong, Oliver B Clarke, Michael T Marty, Anthony A Kossiakoff, George Khelashvili, David L Silver, Filippo Mancia
Nature volume 595, pages315–319 (2021)
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Mar 01 2021
Recombinant Antibody Network Partners with Bristol Myers Squibb to Develop Novel Therapies
The Recombinant Antibody Network (RAN), a consortium comprising research groups from UC San Francisco (UCSF), the University of Chicago, and the University of Toronto have expanded a previous research collaboration with Bristol Myers Squibb, aimed to create and develop high-performance recombinant antibodies against diverse targets in human cells.
The RAN was founded in 2012 by …
Jul 06 2020
Patent of the Week: Improving the Performance of Antibody Fragments
Patent-of-the-week-improving-the-performance-of-antibody-fragments
Antibody fragments, including Fabs, which bind to immune response-triggering substances, or antigens, have demonstrated utility in various research and diagnostic applications. However, their structure limits their use, so researchers have engineered a protein that can be tethered to Fabs to expand their functionality.
The inventors, including Anthony Kossiakoff, a professor of biochemistry and molecular …
Mar 29 2020
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins
Mukherjee S, Erramilli SK, Ammirati M, Alvarez FJD, Fennell KF, Purdy MD, Skrobek BM, Radziwon K, Coukos J, Kang Y, Dutka P, Gao X, Qiu X, Yeager M, Eric Xu H, Han S, Kossiakoff AA
Nat Commun 2020 Mar;11(1):1598
PMID: 32221310
Abstract
We propose the concept of universal fiducials based on a set of pre-made …
Feb 26 2020
Structure and mechanism of the ER-based glucosyltransferase ALG6
Bloch JS, Pesciullesi G, Boilevin J, Nosol K, Irobalieva RN, Darbre T, Aebi M, Kossiakoff AA, Reymond JL, Locher KP
Nature 2020 03;579(7799):443-447
PMID: 32103179
Abstract
In eukaryotic protein N-glycosylation, a series of glycosyltransferases catalyse the biosynthesis of a dolichylpyrophosphate-linked oligosaccharide before its transfer onto acceptor proteins. The final seven steps occur in the lumen …
Jan 02 2020
Anthony Kossiakoff, University of Chicago 2019 Christian B. Anfinsen Award Winner
The Christian B. Anfinsen Award- Sponsored by The Protein Society, recognizes technological achievement or significant methodological advances in the field of protein science.
The recipient of this award in 2019 is Professor Anthony Kossiakoff (University of Chicago). Professor Kossiakoff’s achievements have had broad and sustained impact through the development of innovative technologies and major discoveries …