Tag: Fabs

Engineered Protein-G variants for plug-and-play applications

Tomasz Slezak, Kelly M. O’Leary, Jinyang Li, Ahmed Rohaim, Elena K. Davydova, Anthony A. Kossiakoff

bioRxiv 2024 August 08.

PMID: 39211271 PMCID: PMC11361062 DOI: 10.1101/2024.08.06.606809

We have developed a portfolio of antibody-based modules that can be prefabricated as standalone units and snapped together in plug-and-play fashion to create uniquely powerful multifunctional assemblies. The basic building blocks are …

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Quaternary structure independent folding of voltage-gated ion channel pore domain subunits

Cristina Arrigoni, Marco Lolicato, David Shaya, Ahmed Rohaim, Felix Findeisen, Lam-Kiu Fong, Claire M Colleran, Pawel Dominik, Sangwoo S Kim, Jonathan P Schuermann, William F DeGrado, Michael Grabe, Anthony A Kossiakoff, Daniel L Minor

Nat Struct Mol Biol. 2022 Jun;29(6):537-548.

PMID: 35655098 DOI: 10.1038/s41594-022-00775-x

Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from …

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