Aug 08 2023
Susan A Leonhardt, Michael D Purdy, Jonathan R Grover, Ziwei Yang, Sandra Poulos, William E McIntire, Elizabeth A Tatham, Satchal K Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D Uchil, Andrés Finzi, Alan Rein, Anthony A Kossiakoff, Walther Mothes, Mark Yeager
Nature Communications volume 14, Article number: 4368 (2023)
PMID: 37474505 …
Aug 08 2023
Qiuyan Chen, Christopher T Schafer, Somnath Mukherjee, Martin Gustavsson, Parth Agrawal, Xin-Qiu Yao, Anthony A Kossiakoff, Tracy M Handel, John J G Tesmer
bioRxiv 2023 Jul 19, 2023
PMID: 37502840 PMCID: PMC10370059 DOI: 10.1101/2023.07.18.549504
Atypical chemokine receptor 3 (ACKR3, also known as CXCR7) is a scavenger receptor that regulates extracellular levels of the chemokine CXCL12 …
Aug 03 2023
Satchal K Erramilli, Pawel K Dominik, Chinemerem P Ogbu, Anthony A Kossiakoff, Alex J Vecchio
bioRxiv 2023 Jun 12, 2023
PMID: 37398044 PMCID: PMC10312657 DOI: 10.1101/2023.06.12.544689
Claudins are a family of ∼25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells. Humans have 27 subtypes, which homo- and hetero-oligomerize to …
Jul 24 2023
Satchal K. Erramilli, Pawel K. Dominik, Dawid Deneka , Piotr Tokarz , Sangwoo S. Kim, Bharat G. Reddy, Blazej M. Skrobek , Olivier Dalmas , Eduardo Perozo, Anthony A. Kossiakoff
J Mol Biol. 2023
PMD: 37394032 PMID: 37394032 DOI: 10.1016/j.jmb.2023.168192
CorA, the primary magnesium ion channel in prokaryotes and archaea, is a prototypical homopentameric ion channel that undergoes ion-dependent conformational transitions. CorA adopts five-fold symmetric non-conductive states in the presence of high concentrations of Mg2+, and highly asymmetric …
Apr 03 2023
Karthik Srinivasan, Satchal K. Erramilli, Srinivas Chakravarthy, Adrian Gonzalez, Anthony Kossiakoff, Nicholas Noinaj
Structure. 2023 Mar 17; S0969-2126(23)00078-3.
PMID: 36977410 DOI: 10.1016/j.str.2023.03.002
Roughly 95% of the proteins that make up the chloroplast must be imported from the cytoplasm. The machinery responsible for the translocation of these cargo proteins is called the translocon at the outer …
Feb 13 2023
Szymon P Kordon, Przemysław Dutka, Justyna M Adamska, Sumit J Bandekar, Katherine Leon, Satchal K Erramilli, Brock Adams, Jingxian Li, Anthony A Kossiakoff, Demet Araç
Nat Commun. 2023 Feb 6
PMID: 36746957 PMCID: PMC9902482 DOI: 10.1038/s41467-023-36312-7
Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular regions that bind to multiple ligands to regulate …
Jul 05 2022
Peiqiang Feng, Xudong Wu, Satchal K Erramilli, Joao A Paulo, Pawel Knejski, Steven P Gygi, Anthony A Kossiakoff, Tom A Rapoport
Nature. 2022 Jun 29
PMID: 35768507 DOI: 10.1038/s41586-022-04903-x
Peroxisomes are ubiquitous organelles that house various metabolic reactions and are essential for human health1-4. Luminal peroxisomal proteins are imported from the cytosol by mobile receptors, which then …
Jul 05 2022
Christopher J Bley, Si Nie, George W Mobbs, Stefan Petrovic, Anna T Gres, Xiaoyu Liu, Somnath Mukherjee, Sho Harvey, Ferdinand M Huber, Daniel H Lin, Bonnie Brown, Aaron W Tang, Emily J Rundlet, Ana R Correia, Shane Chen, Saroj G Regmi, Taylor A Stevens, Claudia A Jette, Mary Dasso, Alina Patke, Alexander F Palazzo, Anthony …
Jul 05 2022
Cristina Arrigoni, Marco Lolicato, David Shaya, Ahmed Rohaim, Felix Findeisen, Lam-Kiu Fong, Claire M Colleran, Pawel Dominik, Sangwoo S Kim, Jonathan P Schuermann, William F DeGrado, Michael Grabe, Anthony A Kossiakoff, Daniel L Minor
Nat Struct Mol Biol. 2022 Jun;29(6):537-548.
PMID: 35655098 DOI: 10.1038/s41594-022-00775-x
Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from …
May 13 2022
Marcin Ura, Somnath Mukherjee, Edyta Marcon, Stefan A Koestler, Anthony A Kossiakoff
J Mol Biol. 2022 Apr 22;167602.
PMID: 35469831 DOI: 10.1016/j.jmb.2022.167602
High-performance affinity reagents are essential tools to enable biologists to profile the cellular location and composition of macromolecular complexes undergoing dynamic reorganization. To support further development of such tools, we have assembled a …