Jul 06 2021
Leonie Enderle, Karim H Shalaby, Maryna Gorelik, Alexander Weiss, Levi L Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J Adams, Sachdev S Sidhu
MAbs. Jan-Dec 2021;13(1):1933690. doi: 10.1080/19420862.2021.1933690
PMID: 34190031
In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell …
Jun 16 2021
Rosemary J Cater, Geok Lin Chua, Satchal K Erramilli, James E Keener, Brendon C Choy, Piotr Tokarz, Cheen Fei Chin, Debra Q Y Quek, Brian Kloss, Joseph G Pepe, Giacomo Parisi, Bernice H Wong, Oliver B Clarke, Michael T Marty, Anthony A Kossiakoff, George Khelashvili, David L Silver, Filippo Mancia
Nature volume 595, pages315–319 (2021)
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Jun 04 2021
Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS
J Mol Biol. 2021 Jun 4;433(15):167090. doi: 10.1016/j.jmb.2021.167090.
PMID: 34090922
Members of the αv family of integrins regulate activation of transforming growth factor beta (TGFβ) and are …
Mar 25 2021
Slezak T, Kossiakoff AA
J Mol Biol. 2021 Mar 25;doi: 10.1016/j.jmb.2021.166956.
PMID: 33775667 PMCID: PMC7997149 DOI: 10.1016/j.jmb.2021.166956
Abstract
The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus’ impact is caused by many factors, but the lack of a technology …
Sep 01 2020
Lokareddy RK, Ko YH, Hong N, Doll SG, Paduch M, Niederweis M, Kossiakoff AA, Cingolani G
Acta Crystallogr D Struct Biol. 2020 Sep 1;76(Pt 9):876-888.
PMID: 32876063
Abstract
The genome-packaging motor of tailed bacteriophages and herpesviruses is a multisubunit protein complex formed by several copies of a large (TerL) and a small (TerS) terminase subunit. …
Aug 07 2020
Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC.
Elife. 2020 Aug 7;9:e58464.
PMID: 32762848
Abstract
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains …
Mar 29 2020
Mukherjee S, Erramilli SK, Ammirati M, Alvarez FJD, Fennell KF, Purdy MD, Skrobek BM, Radziwon K, Coukos J, Kang Y, Dutka P, Gao X, Qiu X, Yeager M, Eric Xu H, Han S, Kossiakoff AA
Nat Commun 2020 Mar;11(1):1598
PMID: 32221310
Abstract
We propose the concept of universal fiducials based on a set of pre-made …
Feb 26 2020
Bloch JS, Pesciullesi G, Boilevin J, Nosol K, Irobalieva RN, Darbre T, Aebi M, Kossiakoff AA, Reymond JL, Locher KP
Nature 2020 03;579(7799):443-447
PMID: 32103179
Abstract
In eukaryotic protein N-glycosylation, a series of glycosyltransferases catalyse the biosynthesis of a dolichylpyrophosphate-linked oligosaccharide before its transfer onto acceptor proteins. The final seven steps occur in the lumen …
Dec 02 2019
Kim J, Tan YZ, Wicht KJ, Erramilli SK, Dhingra SK, Okombo J, Vendome J, Hagenah LM, Giacometti SI, Warren AL, Nosol K, Roepe PD, Potter CS, Carragher B, Kossiakoff AA, Quick M, Fidock DA, Mancia F
Nature 2019 Nov;
PMID: 31776516
Abstract
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control …
Nov 30 2019
Dutka P, Mukherjee S, Gao X, Kang Y, de Waal PW, Wang L, Zhuang Y, Melcher K, Zhang C, Xu HE, Kossiakoff AA
Structure 2019 Oct;
PMID: 31669042
Abstract
“Universal” synthetic antibody (sAB)-based fiducial marks have been generated by customized phage display selections to facilitate the rapid structure determination of G protein-coupled receptor (GPCR) signaling …