Oct 05 2026
Newly engineered protein G variants and Fab scaffolds represent a 500-fold increase in binding affinity compared to previous-generation technology.
Fab fragments can be attached together in a plug and play fashion to produce molecular entities having multi‐valency and multi‐specific properties.
Full story: Engineered Multipurpose Antibody Module Platform
Nov 04 2025
News from the University of Chicago
Engineered immune cells could give doctors new precision when fighting tumors.
Researchers at the University of Chicago have developed a modular cancer immunotherapy that can be switched on, off or reprogramed to attack different cancers.
Promising initial testing results, published in Science Advances, demonstrate a “universal” …
May 03 2023
News from the National Academy of Sciences
Newly elected member Anthony A. Kossiakoff; Professor, Department of Biochemistry and Molecular Biology, The University of Chicago
Three University of Chicago faculty members elected to the National Academy of Sciences in 2023
Mar 01 2021
The Recombinant Antibody Network (RAN), a consortium comprising research groups from UC San Francisco (UCSF), the University of Chicago, and the University of Toronto have expanded a previous research collaboration with Bristol Myers Squibb, aimed to create and develop high-performance recombinant antibodies against diverse targets in human cells.
The RAN was founded in …
Jul 06 2020
Patent-of-the-week-improving-the-performance-of-antibody-fragments
Antibody fragments, including Fabs, which bind to immune response-triggering substances, or antigens, have demonstrated utility in various research and diagnostic applications. However, their structure limits their use, so researchers have engineered a protein that can be tethered to Fabs to expand their functionality.
The inventors, including Anthony Kossiakoff, a professor of …
Jan 02 2020
The Christian B. Anfinsen Award- Sponsored by The Protein Society, recognizes technological achievement or significant methodological advances in the field of protein science.
The recipient of this award in 2019 is Professor Anthony Kossiakoff (University of Chicago). Professor Kossiakoff’s achievements have had broad and sustained impact through the development of innovative technologies and …
Dec 11 2019
Absolute Antibody Ltd., an industry-leading provider of recombinant antibody products and services, has announced a partnership with the Recombinant Antibody Network (RAN), a consortium of three expert centers at the University of Chicago, University of Toronto, and UC San Francisco (UCSF) with a common goal to generate recombinant antibodies at a proteome-wide scale.
Jan 29 2013
Rui H, Kossiakoff AA, Im W
Biophysical Journal, Volume 104, Issue 2, pp. 117a-118a
Abstract
Much of multicellular biology depends on communication through extracellular signaling molecules that bind to membrane receptors and trigger intracellular signaling events and cell behaviors. One of the first paradigm systems for understanding how polypeptide hormones bind and activate their receptors was …