Keeping signaling in check

Kossiakoff AA, Rizk S

Structure 2010 Mar;18(3):275-6

PMID: 20223207


Cytokine signaling is triggered by a hormone-induced receptor aggregation process. IL-13 employs an unconventional sequence of steps for assembling its signaling complex to trigger activation and for turning it off. Both these processes involve some unusual molecular recognition features, as discussed by Lupardus et al. (2010).