Mar 08 2010

Keeping signaling in check

Filed under publications

Kossiakoff AA, Rizk S

Structure 2010 Mar;18(3):275-6

Abstract

Cytokine signaling is triggered by a hormone-induced receptor aggregation process. IL-13 employs an unconventional sequence of steps for assembling its signaling complex to trigger activation and for turning it off. Both these processes involve some unusual molecular recognition features, as discussed by Lupardus et al. (2010).

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