Tag: Glycobiology

Structural insights into translocation and tailored synthesis of hyaluronan

Ireneusz Górniak, Zachery Stephens, Satchal K. Erramilli, Tomasz Gawda, Anthony A. Kossiakoff & Jochen Zimmer

Nature Structural & Molecular Biology (2024)

PMID: 39322765 DOI: 10.1038/s41594-024-01389-1

Hyaluronan (HA) is an essential component of the vertebrate extracellular matrix. It is a heteropolysaccharide of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) reaching several megadaltons in healthy tissues. HA is …

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Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Joël S Bloch, Alan John, Runyu Mao, Somnath Mukherjee, Jérémy Boilevin, Rossitza N Irobalieva, Tamis Darbre, Nichollas E Scott, Jean-Louis Reymond, Anthony A Kossiakoff, Ethan D Goddard-Borger, Kaspar P Locher

Nat Chem Biol. 2023 Jan 5

PMID: 36604564 DOI: 10.1038/s41589-022-01219-9

C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins …

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