Tag: G protein-coupled receptors

Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Szymon P Kordon, Kristina Cechova, Sumit J Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A Kossiakoff, Reza Vafabakhsh, Demet Araç

Nature Communications 2024 Dec 4;15:10545.

PMID: 39627215 PMCID: PMC11615224 DOI: 10.1038/s41467-024-54836-4

Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECRs) containing a …

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