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Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo

Rizk SS, Misiura A, Paduch M, Kossiakoff AA

Bioconjug. Chem. 2012 Jan;23(1):42-6

PMID: 22175275

Abstract

The use of proteins or nucleic acids as therapeutic agents has been severely hampered by their intrinsic inability to cross the cell membrane. Moreover, common techniques for driving the delivery of macromolecules lack the ability to distinguish between healthy and …

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