Tag: synthetic antibody fragment

Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels

Ahmed Rohaim, Tomasz Slezak, Young Hoon Koh, Lydia Blachowicz, Anthony A Kossiakoff, Benoît Roux

J Gen Physiol. 2022 Apr 4;154(4):e202112965.

PMID: 35234830 DOI: 10.1085/jgp.202112965

Engineered antibody fragments (Fabs) have made major impacts on structural biology research, particularly to aid structural determination of membrane proteins. Nonetheless, Fabs generated by traditional monoclonal technology suffer from challenges of routine …

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