Tag: Mechanisms of disease

Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

Hongtao Liu, Rossitza N. Irobalieva, Rose Bang-Sørensen, Kamil Nosol, Somnath Mukherjee, Parth Agrawal, Bruno Stieger, Anthony A. Kossiakoff & Kaspar P. Locher

Cell Research (2022) 0:1–4

PMID: 35726088 DOI: 10.1038/s41422-022-00680-4

The sodium taurocholate (TC) co-transporting polypeptide NTCP (SLC10A1) is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood plasma …

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