Apr 03 2024
Nature Communications volume 15, Article number: 2476 (2024)
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P Locher
PMID: 38509088 PMCID: PMC10954734 DOI: 10.1038/s41467-024-46706-w
Cellular entry of the hepatitis B and D viruses (HBV/HDV) …
Apr 03 2024
Szymon P. Kordon, Kristina Cechova, Sumit J. Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A. Kossiakoff, Reza Vafabakhsh, and Demet Araç
bioRxiv Preprint. 2024 Feb 26
PMID: 38464178 DOI: 10.1101/2024.02.25.581807
Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECR) containing a conserved …
Aug 08 2023
Susan A Leonhardt, Michael D Purdy, Jonathan R Grover, Ziwei Yang, Sandra Poulos, William E McIntire, Elizabeth A Tatham, Satchal K Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D Uchil, Andrés Finzi, Alan Rein, Anthony A Kossiakoff, Walther Mothes, Mark Yeager
Nature Communications volume 14, Article number: 4368 (2023)
PMID: 37474505 …
Aug 08 2023
Qiuyan Chen, Christopher T Schafer, Somnath Mukherjee, Martin Gustavsson, Parth Agrawal, Xin-Qiu Yao, Anthony A Kossiakoff, Tracy M Handel, John J G Tesmer
bioRxiv 2023 Jul 19, 2023
PMID: 37502840 PMCID: PMC10370059 DOI: 10.1101/2023.07.18.549504
Atypical chemokine receptor 3 (ACKR3, also known as CXCR7) is a scavenger receptor that regulates extracellular levels of the chemokine CXCL12 …
Jul 24 2023
Satchal K. Erramilli, Pawel K. Dominik, Dawid Deneka , Piotr Tokarz , Sangwoo S. Kim, Bharat G. Reddy, Blazej M. Skrobek , Olivier Dalmas , Eduardo Perozo, Anthony A. Kossiakoff
J Mol Biol. 2023
PMD: 37394032 PMID: 37394032 DOI: 10.1016/j.jmb.2023.168192
CorA, the primary magnesium ion channel in prokaryotes and archaea, is a prototypical homopentameric ion channel that undergoes ion-dependent conformational transitions. CorA adopts five-fold symmetric non-conductive states in the presence of high concentrations of Mg2+, and highly asymmetric …
Mar 23 2023
David M Kern, Julia Bleier, Somnath Mukherjee, Jennifer M Hill, Anthony A Kossiakoff, Ehud Y Isacoff, Stephen G Brohawn
Nat Struct Mol Biol 2023 Mar 16
PMID: 36928458 DOI: 10.1038/s41594-023-00944-6
Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously expressed in vertebrate cells as …
Jul 05 2022
Christopher J Bley, Si Nie, George W Mobbs, Stefan Petrovic, Anna T Gres, Xiaoyu Liu, Somnath Mukherjee, Sho Harvey, Ferdinand M Huber, Daniel H Lin, Bonnie Brown, Aaron W Tang, Emily J Rundlet, Ana R Correia, Shane Chen, Saroj G Regmi, Taylor A Stevens, Claudia A Jette, Mary Dasso, Alina Patke, Alexander F Palazzo, Anthony …
Jan 04 2022
Elena K Davydova
Review Biochemistry (Mosc). 2022 Jan;87(Suppl 1):S146-S110
PMID: 35501993 PMCID: PMC8802281 DOI: 10.1134/S0006297922140127
Functional Protein Engineering became the hallmark of biomolecule manipulation in the new millennium, building on and surpassing the underlying structural DNA manipulation and recombination techniques developed and employed in the last decades of the 20th century. Because of their prominence …
Dec 06 2021
Joël S Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V Filippova, Martina Niederer, Els Pardon, Jan Steyaert, Anthony A Kossiakoff, Kaspar P Locher
Proc Natl Acad Sci U S A. 2021 Nov 23;118(47)
PMID: 34782475 DOI: 10.1073/pnas.2115435118
With conformation-specific nanobodies being used for a wide range of structural, biochemical, and cell biological applications, there is a …
Jul 06 2021
Leonie Enderle, Karim H Shalaby, Maryna Gorelik, Alexander Weiss, Levi L Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J Adams, Sachdev S Sidhu
MAbs. Jan-Dec 2021;13(1):1933690. doi: 10.1080/19420862.2021.1933690
PMID: 34190031
In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell …