Kossiakoff Lab

University of Chicago

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Publications

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Year: 1992

  • Eigenbrot, C., Randal, M. & Kossiakoff, A. A. (1992). Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor. Proteins, 14(1), 75-87. [More] [Digital version]
  • Kossiakoff, A. A., Randal, M., Guenot, J. & Eigenbrot, C. (1992). Variability of conformations at crystal contacts in BPTI represent true low-energy structures: correspondence among lattice packing and molecular dynamics structures. Proteins, 14(1), 65-74. [More] [Digital version]
  • Kossiakoff, A. A., Sintchak, M. D., Shpungin, J. & Presta, L. G. (1992). Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin. Proteins, 12(3), 223-236. [More] [Digital version]
  • de Vos, A. M., Ultsch, M. H., Kelley, R. F., Padmanabhan, K., Tulinsky, A., Westbrook, M. L. et al. (1992). Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. Biochemistry, 31(1), 270-279. [More] [Digital version]
  • de Vos, A. M., Ultsch, M. & Kossiakoff, A. A. (1992). Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science {(New} York, {N.Y.)}, 255(5042), 306-312. [More] [Digital version]
  • {Finer-Moore}, J. S., Kossiakoff, A. A., Hurley, J. H., Earnest, T. & Stroud, R. M. (1992). Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction. Proteins, 12(3), 203-222. [More] [Digital version]

Year: 1991

  • Eigenbrot, C., Randal, M., Quan, C., Burnier, J., {O'Connell}, L., Rinderknecht, E. et al. (1991). X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants. Journal of Molecular Biology, 221(1), 15-21. [More] [Digital version]
  • Kossiakoff, A. A., Ultsch, M., White, S. & Eigenbrot, C. (1991). Neutron structure of subtilisin {BPN':} effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements. Biochemistry, 30(5), 1211-1221. [More] [Digital version]
  • Ultsch, M., de Vos, A. M. & Kossiakoff, A. A. (1991). Crystals of the complex between human growth hormone and the extracellular domain of its receptor. Journal of Molecular Biology, 222(4), 865-868. [More] [Digital version]

Year: 1990

  • Eigenbrot, C., Randal, M. & Kossiakoff, A. A. (1990). Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the {C30A/C51A} mutant of basic pancreatic trypsin inhibitor at 1.6 A. Protein Engineering, 3(7), 591-598. [More] [Digital version]
  • Hynes, T. R., Randal, M., Kennedy, L. A., Eigenbrot, C. & Kossiakoff, A. A. (1990). X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor. Biochemistry, 29(43), 10018-10022. [More] [Digital version]
  • Katz, B. & Kossiakoff, A. A. (1990). Crystal structures of subtilisin {BPN'} variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis. Proteins, 7(4), 343-357. [More] [Digital version]
  • Kossiakoff, A. A., Shpungin, J. & Sintchak, M. D. (1990). Hydroxyl hydrogen conformations in trypsin determined by the neutron diffraction solvent difference map method: relative importance of steric and electrostatic factors in defining hydrogen-bonding geometries. Proceedings of the National Academy of Sciences of the United States of America, 87(12), 4468-4472. [More] [Digital version]

Year: 1988

  • Kossiakoff, A. A. (1988a). Tertiary structure is a principal determinant to protein deamidation. Science {(New} York, {N.Y.)}, 240(4849), 191-194. [More] [Digital version]
  • Kossiakoff, A. A. (1988b). The use of neutrons to show how proteins work. Basic Life Sciences, 46, 63-78. [More] [Digital version]

Year: 1986

  • Kossiakoff, A. A. (1986). Protein dynamics investigated by neutron diffraction. Methods in Enzymology, 131, 433-447. [More] [Digital version]
  • Shpungin, J. & Kossiakoff, A. A. (1986). A method of solvent structure analysis for proteins using D2O-H2O neutron difference maps. Methods in Enzymology, 127, 329-342. [More] [Digital version]

Year: 1985

  • Kossiakoff, A. A. (1985). The application of neutron crystallography to the study of dynamic and and hydration properties of proteins. Annual Review of Biochemistry, 54, 1195-1227. [More] [Digital version]

Year: 1984

  • Kossiakoff, A. A. (1984). Use of the neutron {diffraction--H/D} exchange technique to determine the conformational dynamics of trypsin. Basic Life Sciences, 27, 281-304. [More] [Digital version]
  • Kossiakoff, A. A. & Shteyn, S. (1984). Effect of protein packing structure on side-chain methyl rotor conformations. Nature, 311(5986), 582-583. [More] [Digital version]

Year: 1983

  • Kossiakoff, A. A. (1983). Neutron protein crystallography: advances in methods and applications. Annual Review of Biophysics and Bioengineering, 12, 159-182. [More] [Digital version]

Year: 1982

  • Kossiakoff, A. A. (1982). Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique. Nature, 296(5859), 713-721. [More] [Digital version]

Year: 1981

  • Kossiakoff, A. A. & Spencer, S. A. (1981). Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin. Biochemistry, 20(22), 6462-6474. [More] [Digital version]

Year: 1980

  • Kossiakoff, A. A. & Spencer, S. A. (1980). Neutron diffraction identifies His 57 as the catalytic base in trypsin. Nature, 288(5789), 414-416. [More] [Digital version]

Year: 1977

  • Kossiakoff, A. A., Chambers, J. L., Kay, L. M. & Stroud, R. M. (1977). Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry, 16(4), 654-664. [More] [Digital version]
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