Kossiakoff Lab

University of Chicago

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Publications

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Year: 2004

  • Bernat, B., Sun, M., Dwyer, M., Feldkamp, M. & Kossiakoff, A. A. (2004). Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries. Biochemistry, 43(20), 6076-6084. [More] [Digital version]

Year: 2003

  • Bernat, B., Pal, G., Sun, M. & Kossiakoff, A. A. (2003). Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proceedings of the National Academy of Sciences of the United States of America, 100(3), 952-957. [More] [Digital version]
  • Pal, G., Kossiakoff, A. A. & Sidhu, S. S. (2003). The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. Journal of Molecular Biology, 332(1), 195-204. [More] [Digital version]
  • Pál, G., Santamaria, F., Kossiakoff, A. A. & Lu, W. (2003). The first semi-synthetic serine protease made by native chemical ligation. Protein Expression and Purification, 29(2), 185-192. [More] [Digital version]
  • Walsh, S. T., Jevitts, L. M., Sylvester, J. E. & Kossiakoff, A. A. (2003). Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Science: A Publication of the Protein Society, 12(9), 1960-1970. [More] [Digital version]

Year: 2001

  • Dwyer, J. J., Dwyer, M. A. & Kossiakoff, A. A. (2001). High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy. Biochemistry, 40(45), 13491-13500. [More] [Digital version]
  • Randal, M. & Kossiakoff, A. A. (2001). The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex. Structure {(London,} England: 1993), 9(2), 155-163. [More] [Digital version]

Year: 2000

  • Dwyer, M. A., Lu, W., Dwyer, J. J. & Kossiakoff, A. A. (2000). Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity. Chemistry & Biology, 7(4), 263-274. [More] [Digital version]
  • Elkins, P. A., Christinger, H. W., Sandowski, Y., Sakal, E., Gertler, A., de Vos, A. M. et al. (2000). Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nature Structural Biology, 7(9), 808-815. [More] [Digital version]
  • Lu, W. Y., Starovasnik, M. A., Dwyer, J. J., Kossiakoff, A. A., Kent, S. B. & Lu, W. (2000). Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis. Biochemistry, 39(13), 3575-3584. [More] [Digital version]
  • Randal, M. & Kossiakoff, A. A. (2000). The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Acta Crystallographica. Section D, Biological Crystallography, 56(Pt 1), 14-24. [More] [Digital version]

Year: 1998

  • Christinger, H. W., Elkins, P. A., Sandowski, Y., Sakal, E., Gertler, A., Kossiakoff, A. A. et al. (1998). Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor. Acta Crystallographica. Section D, Biological Crystallography, 54(Pt 6 Pt 2), 1408-1411. [More] [Digital version]
  • Kossiakoff, A. A. & Vos, A. M. (1998). Structural basis for cytokine hormone-receptor recognition and receptor activation. Advances in Protein Chemistry, 52, 67-108. [More] [Digital version]
  • Randal, M. & Kossiakoff, A. A. (1998). Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor. Protein Science: A Publication of the Protein Society, 7(4), 1057-1060. [More] [Digital version]

Year: 1997

  • Scheidig, A. J., Hynes, T. R., Pelletier, L. A., Wells, J. A. & Kossiakoff, A. A. (1997). Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor {(APPI)} and basic pancreatic trypsin inhibitor {(BPTI):} engineering of inhibitors with altered specificities. Protein Science: A Publication of the Protein Society, 6(9), 1806-1824. [More] [Digital version]

Year: 1996

  • {McDowell}, R. S. & Kossiakoff, A. A. (1996). Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures. Basic Life Sciences, 64, 273-287. [More] [Digital version]

Year: 1995

  • Kossiakoff, A. A. (1995). Structure of the growth hormone-receptor complex and mechanism of receptor signaling. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine, 36(6 Suppl), 14S-16S. [More] [Digital version]
  • {McDowell}, R. S. & Kossiakoff, A. A. (1995). A comparison of neutron diffraction and molecular dynamics structures: hydroxyl group and water molecule orientations in trypsin. Journal of Molecular Biology, 250(4), 553-570. [More] [Digital version]

Year: 1994

  • Gamble, T. R., Clauser, K. R. & Kossiakoff, A. A. (1994). The production and X-ray structure determination of perdeuterated Staphylococcal nuclease. Biophysical Chemistry, 53(1-2), 15-25. [More] [Digital version]
  • Kossiakoff, A. A., Somers, W., Ultsch, M., Andow, K., Muller, Y. A. & Vos, A. M. (1994). Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors. Protein Science: A Publication of the Protein Society, 3(10), 1697-1705. [More] [Digital version]
  • Somers, W., Ultsch, M., Vos, A. M. & Kossiakoff, A. A. (1994). The X-ray structure of a growth hormone-prolactin receptor complex. Nature, 372(6505), 478-481. [More] [Digital version]
  • Ultsch, M. H., Somers, W., Kossiakoff, A. A. & de Vos, A. M. (1994). The crystal structure of affinity-matured human growth hormone at 2 A resolution. Journal of Molecular Biology, 236(1), 286-299. [More] [Digital version]

Year: 1993

  • Eigenbrot, C., Randal, M., Presta, L., Carter, P. & Kossiakoff, A. A. (1993). X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. Journal of Molecular Biology, 229(4), 969-995. [More] [Digital version]
  • Kossiakoff, A. A., Hynes, T. & de Vos, A. (1993). Molecular recognition in biological systems: from activation to inhibition. Biochemical Society Transactions, 21 ( Pt 3)(3), 614-618. [More] [Digital version]

Year: 1992

  • Eigenbrot, C. & Kossiakoff, A. A. (1992). Structural consequences of mutation. Current Opinion in Biotechnology, 3(4), 333-337. [More] [Digital version]
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