Kossiakoff Lab

University of Chicago

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Publications

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Year: 2010

  • Kossiakoff, A. A. & Rizk, S. (2010). Keeping signaling in check. Structure {(London,} England: 1993), 18(3), 275-276. [More] [Digital version]

Year: 2009

  • Bang, D., Tereshko, V., Kossiakoff, A. A. & Kent, S. B. (2009). Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, {[V15A]crambin-alpha-carboxamide}. Molecular {bioSystems}, 5(7), 750-756. [More] [Digital version]
  • Horn, J. R., Sosnick, T. R. & Kossiakoff, A. A. (2009). Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proceedings of the National Academy of Sciences of the United States of America, 106(8), 2559-2564. [More] [Digital version]
  • Mandal, K., Pentelute, B. L., Tereshko, V., Thammavongsa, V., Schneewind, O., Kossiakoff, A. A. et al. (2009). Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Science: A Publication of the Protein Society, 18(6), 1146-1154. [More] [Digital version]
  • Mandal, K., Pentelute, B. L., Tereshko, V., Kossiakoff, A. A. & Kent, S. B. (2009). X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. Journal of the American Chemical Society, 131(4), 1362-1363. [More] [Digital version]
  • Rizk, S. S., Luchniak, A., Uysal, S., Brawley, C. M., Rock, R. S. & Kossiakoff, A. A. (2009). An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 106(27), 11011-11015. [More] [Digital version]

Year: 2008

  • Kossiakoff, A. A. & Koide, S. (2008). Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces. Current Opinion in Structural Biology, 18(4), 499-506. [More] [Digital version]
  • Pentelute, B. L., Gates, Z. P., Tereshko, V., Dashnau, J. L., Vanderkooi, J. M., Kossiakoff, A. A. et al. (2008). X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. Journal of the American Chemical Society, 130(30), 9695-9701. [More] [Digital version]
  • Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S. & Kossiakoff, A. A. (2008). Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody {(VHH)} scaffold. Protein Science: A Publication of the Protein Society, 17(7), 1175-1187. [More] [Digital version]
  • Ye, ., Tereshko, V., Frederiksen, J. K., Koide, A., Fellouse, F. A., Sidhu, S. S. et al. (2008). Synthetic antibodies for specific recognition and crystallization of structured RNA. Proceedings of the National Academy of Sciences of the United States of America, 105(1), 82-87. [More] [Digital version]

Year: 2007

  • Fellouse, F. A., Esaki, K., Birtalan, S., Raptis, D., Cancasci, V. J., Koide, A. et al. (2007). High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. Journal of Molecular Biology, 373(4), 924-940. [More] [Digital version]
  • Koide, A., Tereshko, V., Uysal, S., Margalef, K., Kossiakoff, A. A. & Koide, S. (2007). Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. Journal of Molecular Biology, 373(4), 941-953. [More] [Digital version]
  • Sidhu, S. S. & Kossiakoff, A. A. (2007). Exploring and designing protein function with restricted diversity. Current Opinion in Chemical Biology, 11(3), 347-354. [More] [Digital version]

Year: 2006

  • Bang, D., Gribenko, A. V., Tereshko, V., Kossiakoff, A. A., Kent, S. B. & Makhatadze, G. I. (2006). Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nature Chemical Biology, 2(3), 139-143. [More] [Digital version]
  • Horn, J. R., Kraybill, B., Petro, E. J., Coales, S. J., Morrow, J. A., Hamuro, Y. et al. (2006). The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by {H/D} exchange mass spectrometry. Biochemistry, 45(28), 8488-8498. [More] [Digital version]
  • Pál, G., K Kouadio, ., Artis, D. R., Kossiakoff, A. A. & Sidhu, S. S. (2006). Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. The Journal of Biological Chemistry, 281(31), 22378-22385. [More] [Digital version]
  • Rizvi, S. A., Tereshko, V., Kossiakoff, A. A. & Kozmin, S. A. (2006). Structure of bistramide A-actin complex at a 1.35 angstroms resolution. Journal of the American Chemical Society, 128(12), 3882-3883. [More] [Digital version]
  • Walsh, S. T. & Kossiakoff, A. A. (2006). Crystal structure and site 1 binding energetics of human placental lactogen. Journal of Molecular Biology, 358(3), 773-784. [More] [Digital version]

Year: 2005

  • Bang, D., Makhatadze, G. I., Tereshko, V., Kossiakoff, A. A. & Kent, S. B. (2005). Total chemical synthesis and X-ray crystal structure of a protein diastereomer: {[D-Gln} 35]ubiquitin. Angewandte Chemie {(International} Ed. in English), 44(25), 3852-3856. [More] [Digital version]
  • Gopal, B., Madan, L. L., Betz, S. F. & Kossiakoff, A. A. (2005). The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s). Biochemistry, 44(1), 193-201. [More] [Digital version]
  • Pál, G., Ultsch, M. H., Clark, K. P., Currell, B., Kossiakoff, A. A. & Sidhu, S. S. (2005). Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. Journal of Molecular Biology, 347(3), 489-494. [More] [Digital version]
  • Pál, G., Fong, ., Kossiakoff, A. A. & Sidhu, S. S. (2005). Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein Science: A Publication of the Protein Society, 14(9), 2405-2413. [More] [Digital version]
  • K Kouadio, ., Horn, J. R., Pal, G. & Kossiakoff, A. A. (2005). Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. The Journal of Biological Chemistry, 280(27), 25524-25532. [More] [Digital version]

Year: 2004

  • Kossiakoff, A. A. (2004). The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Advances in Protein Chemistry, 68, 147-169. [More] [Digital version]
  • Walsh, S. T., Sylvester, J. E. & Kossiakoff, A. A. (2004). The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17078-17083. [More] [Digital version]
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