Kossiakoff Lab

University of Chicago

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Year: 2013

  • AK, S., A, M., AC, K., K, X., RI, R., WC, T. et al. (2013). Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.. Nature, 497(7447), 137-141. [More] [Digital version]
  • M, P., A, K., S, U., SS, R., S, K. & AA, K. (2013). Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. Methods., 60(1), 3-14. [More] [Digital version]

Year: 2012

  • SS, R., A, M., M, P. & AA., K. (2012). Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo. Bioconjug Chem, 23(1), 42-46. [More] [Digital version]

Year: 2011

  • S, U., LG, C., DM, C., S, K., AA, K. & E., P. (2011). Mechanism of activation gating in the full-length KcsA K+ channel. Proc Natl Acad Sci U S A, 108(29), 11896-11899. [More] [Digital version]
  • SS, R., M, P., JH, H., EM, D., A, S. & AA, K. (2011). Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.. Nat Struct Mol Biol, 18(4), 437-442. [More] [Digital version]
  • Y, K., EM, D., DM, S., NB, S., J, Y., SS, S. et al. (2011). A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.. Nat Struct Mol Biol., 18(1), 100-106. [More] [Digital version]

Year: 2010

  • CM, B., S, U., AA, K. & RS, R. (2010). Characterization of engineered actin binding proteins that control filament assembly and structure.. PLoS One, 5(11). [More] [Digital version]
  • Kossiakoff, A. A. & Rizk, S. (2010). Keeping signaling in check. Structure {(London,} England: 1993), 18(3), 275-276. [More] [Digital version]

Year: 2009

  • Bang, D., Tereshko, V., Kossiakoff, A. A. & Kent, S. B. (2009). Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, {[V15A]crambin-alpha-carboxamide}. Molecular {bioSystems}, 5(7), 750-756. [More] [Digital version]
  • Horn, J. R., Sosnick, T. R. & Kossiakoff, A. A. (2009). Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proceedings of the National Academy of Sciences of the United States of America, 106(8), 2559-2564. [More] [Digital version]
  • Mandal, K., Pentelute, B. L., Tereshko, V., Thammavongsa, V., Schneewind, O., Kossiakoff, A. A. et al. (2009). Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Science: A Publication of the Protein Society, 18(6), 1146-1154. [More] [Digital version]
  • Mandal, K., Pentelute, B. L., Tereshko, V., Kossiakoff, A. A. & Kent, S. B. (2009). X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. Journal of the American Chemical Society, 131(4), 1362-1363. [More] [Digital version]
  • Rizk, S. S., Luchniak, A., Uysal, S., Brawley, C. M., Rock, R. S. & Kossiakoff, A. A. (2009). An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 106(27), 11011-11015. [More] [Digital version]

Year: 2008

  • Kossiakoff, A. A. & Koide, S. (2008). Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces. Current Opinion in Structural Biology, 18(4), 499-506. [More] [Digital version]
  • Pentelute, B. L., Gates, Z. P., Tereshko, V., Dashnau, J. L., Vanderkooi, J. M., Kossiakoff, A. A. et al. (2008). X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. Journal of the American Chemical Society, 130(30), 9695-9701. [More] [Digital version]
  • Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S. & Kossiakoff, A. A. (2008). Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody {(VHH)} scaffold. Protein Science: A Publication of the Protein Society, 17(7), 1175-1187. [More] [Digital version]
  • Ye, ., Tereshko, V., Frederiksen, J. K., Koide, A., Fellouse, F. A., Sidhu, S. S. et al. (2008). Synthetic antibodies for specific recognition and crystallization of structured RNA. Proceedings of the National Academy of Sciences of the United States of America, 105(1), 82-87. [More] [Digital version]

Year: 2007

  • Fellouse, F. A., Esaki, K., Birtalan, S., Raptis, D., Cancasci, V. J., Koide, A. et al. (2007). High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. Journal of Molecular Biology, 373(4), 924-940. [More] [Digital version]
  • Koide, A., Tereshko, V., Uysal, S., Margalef, K., Kossiakoff, A. A. & Koide, S. (2007). Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. Journal of Molecular Biology, 373(4), 941-953. [More] [Digital version]
  • Sidhu, S. S. & Kossiakoff, A. A. (2007). Exploring and designing protein function with restricted diversity. Current Opinion in Chemical Biology, 11(3), 347-354. [More] [Digital version]

Year: 2006

  • Bang, D., Gribenko, A. V., Tereshko, V., Kossiakoff, A. A., Kent, S. B. & Makhatadze, G. I. (2006). Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nature Chemical Biology, 2(3), 139-143. [More] [Digital version]
  • Horn, J. R., Kraybill, B., Petro, E. J., Coales, S. J., Morrow, J. A., Hamuro, Y. et al. (2006). The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by {H/D} exchange mass spectrometry. Biochemistry, 45(28), 8488-8498. [More] [Digital version]
  • Pál, G., K Kouadio, ., Artis, D. R., Kossiakoff, A. A. & Sidhu, S. S. (2006). Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. The Journal of Biological Chemistry, 281(31), 22378-22385. [More] [Digital version]
  • Rizvi, S. A., Tereshko, V., Kossiakoff, A. A. & Kozmin, S. A. (2006). Structure of bistramide A-actin complex at a 1.35 angstroms resolution. Journal of the American Chemical Society, 128(12), 3882-3883. [More] [Digital version]
  • Walsh, S. T. & Kossiakoff, A. A. (2006). Crystal structure and site 1 binding energetics of human placental lactogen. Journal of Molecular Biology, 358(3), 773-784. [More] [Digital version]
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